The Resource The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier

The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier

Label
The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report
Title
The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens
Title remainder
final report
Statement of responsibility
Robert D. Johnson, Russell J. Lewis, Mike K. Angier
Title variation
Liquid chromatography/mass spectrometry quantification of vardenafil (Levitra®) in postmortem biological specimens
Creator
Contributor
Subject
Language
eng
Summary
During the investigation of aviation accidents, postmortem specimens from accident victims are submitted to the Federal Aviation Administration's Civil Aerospace Medical Institute (CAMI) for toxicological analysis. As new medications are introduced to the market and are subsequently used by aviation accident victims, CAMI's forensic toxicology laboratory is tasked with developing analytical methods for the determination of these compounds. This report presents a rapid and reliable method for the identification and quantitation of vardenafil (Levitra®) in biological specimens. This procedure utilizes sildenafil-d8, which structurally is closely related to vardenafil, as an internal standard for more accurate and reliable quantitation. The method incorporates solid phase extraction and LC/MS/MS and MS/MS/MS utilizing an atmospheric pressure chemical ionization ion trap mass spectrometer in the positive chemical ionization mode. Solid-phase extraction proved to be exceptionally efficient providing recoveries that ranged from 94-97%. The limit of detection for vardenafil was determined to be 0.19 ng/mL. The linear dynamic range for this compound was 0.39-200 ng/mL. This method was successfully applied to postmortem fluid and tissue specimens obtained from an aviation accident victim. This novel analytical procedure proved to be simple, accurate, and robust for the identification and quantitation of vardenafil in postmortem specimens
Cataloging source
GPO
http://library.link/vocab/creatorName
Johnson, Robert D.
Funding information
Performed by FAA Civil Aerospace Medical Institute, Oklahoma City, OK, under approved task no.
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
http://library.link/vocab/relatedWorkOrContributorName
  • Lewis, Russell J
  • Angier, Mike K
  • United States
  • United States
  • Civil Aerospace Medical Institute
http://library.link/vocab/subjectName
  • Forensic toxicology
  • Impotence
  • Aircraft accidents
Label
The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier
Link
http://purl.access.gpo.gov/GPO/LPS74559
Instantiates
Publication
Note
  • Tile from title screen (viewed on Sept. 27, 2006)
  • "July 2006"
  • "DOT/FAA/AM-06/17."
Bibliography note
Includes bibliographical references (page 10)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
17473129
Dimensions
unknown
Extent
i, 10 pages
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
digital, PDF file
Specific material designation
remote
System details
Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/27/06: http://www.faa.gov/library/reports/medical/oamtech reports/2000s/media/200617.pdf; current access via PURL
Label
The LC/MS quantification of vardenafil (Levitra®) in postmortem biological specimens : final report, Robert D. Johnson, Russell J. Lewis, Mike K. Angier
Link
http://purl.access.gpo.gov/GPO/LPS74559
Publication
Note
  • Tile from title screen (viewed on Sept. 27, 2006)
  • "July 2006"
  • "DOT/FAA/AM-06/17."
Bibliography note
Includes bibliographical references (page 10)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
black and white
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
17473129
Dimensions
unknown
Extent
i, 10 pages
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
digital, PDF file
Specific material designation
remote
System details
Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/27/06: http://www.faa.gov/library/reports/medical/oamtech reports/2000s/media/200617.pdf; current access via PURL

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