The Resource Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis

Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis

Label
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report
Title
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS
Title remainder
final report
Statement of responsibility
Robert D. Johnson, Russell J. Lewis
Creator
Contributor
Subject
Language
eng
Summary
Hypertension is a growing medical concern in the United States. With an increasing number of Americans suffering from hypertension every year, the use of antihypertensive medications such as beta-blockers has increased as well. Three beta-blocker medications--atenolol, metoprolol, and propranolol--were among the 200 most prescribed drugs in the United States in 2003, ranked 4, 14, and 165, respectively. Pilots that successfully manage their hypertension either with diet, exercise, and/or medication may remain medically certified to operate an aircraft. However, these pilots are closely monitored to ensure that their hypertension is properly controlled. The FAA classifies approximately 8% of all active civil aviation pilots as "hypertensive with medication." Toxicological evaluation of postmortem samples obtained from pilots is an important part of the investigation of fatal civil aviation accidents. During this evaluation it is not uncommon to detect beta-blocker compounds such as atenolol, metoprolol, or propranolol in the submitted biological samples. In forensic toxicology laboratories, these compounds are most commonly confirmed and/or quantitated by gas chromatography with mass spectrometric detection (GC/MS). Liquid chromatography coupled with mass spectrometric detection (LC/MS), however, is becoming increasingly more prevalent in the field of forensic toxicology and is considered a superior alternative to GC/MS for the analysis of many compounds. There are very few analytical LC/MS methods published for the determination of beta-blockers from biological specimens. Furthermore, we were unable to find any citation for the toxicological determination of beta-blockers in postmortem fluid and tissue specimens using LC/MS; in particular, atmospheric pressure chemical ionization (APCI) in conjunction with ion trap MS. This manuscript describes the validation and application of such a method
Additional physical form
Also available in print.
Cataloging source
NLM
http://library.link/vocab/creatorDate
1974-
http://library.link/vocab/creatorName
Johnson, Robert D.
Funding information
Performed by FAA Civil Aerospace Medical Institute under approved task no.
Government publication
federal national government publication
Illustrations
illustrations
Index
no index present
Literary form
non fiction
Nature of contents
  • dictionaries
  • bibliography
  • technical reports
http://library.link/vocab/relatedWorkOrContributorName
  • Lewis, Russell J
  • United States
  • Civil Aerospace Medical Institute
http://library.link/vocab/subjectName
  • Adrenergic beta blockers
  • Aircraft accidents
  • Hypertension
  • Propanolamines
Label
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis
Link
http://purl.access.gpo.gov/GPO/LPS74592
Instantiates
Publication
Note
  • Title from PDF t.p. (viewed May 24, 2006)
  • "May 2005."
  • "DOT/FAA/AM-05/10."
Bibliography note
Includes bibliographical references (pages 6-7)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
17471750
Dimensions
unknown
Extent
i, 18 pages
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
digital, PDF file
Specific material designation
remote
System details
Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/28/06: http://www.faa.gov/library/reports/medical/oamtech reports/2000s/media/0510.pdf; current access via PURL
Label
Simultaneous quantitation of atenolol, metoprolol, and propranolol in biological matrices via LC/MS : final report, Robert D. Johnson, Russell J. Lewis
Link
http://purl.access.gpo.gov/GPO/LPS74592
Publication
Note
  • Title from PDF t.p. (viewed May 24, 2006)
  • "May 2005."
  • "DOT/FAA/AM-05/10."
Bibliography note
Includes bibliographical references (pages 6-7)
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Color
multicolored
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
17471750
Dimensions
unknown
Extent
i, 18 pages
Form of item
electronic
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
digital, PDF file
Specific material designation
remote
System details
Mode of access: Internet from the Office of Aerospace Medicine web site. Address as of 9/28/06: http://www.faa.gov/library/reports/medical/oamtech reports/2000s/media/0510.pdf; current access via PURL

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