The Resource First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005, Ahmet Sen ... [and others]

First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005, Ahmet Sen ... [and others]

Label
First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005
Title
First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005
Statement of responsibility
Ahmet Sen ... [and others]
Creator
Contributor
Subject
Language
eng
Summary
First-generation H1-receptor antagonists are popularly used for alleviating allergy and cold symptoms, but these antihistaminics cause drowsiness and sedation. Such side effects could impair performance and, thus, could be the cause or a factor in accidents. Therefore, the prevalence of these antagonists was evaluated in aviation accident pilot fatalities. During civil aircraft accident investigations, postmortem samples from pilots involved in fatal aviation accidents are submitted to the Civil Aerospace Medical Institute (CAMI) for toxicological analyses. These analytical findings are stored in a database. This CAMI Toxicology Database was examined for the presence of the first-generation antihistamines in pilot fatalities of civil aircraft accidents that occurred during a 16-year (1990-2005) period. Of 5383 fatal aviation accidents from which CAMI received specimens, there were 338 accidents wherein pilot fatalities (cases) were found to contain the antihistaminics brompheniramine, chlorpheniramine, diphenhydramine, doxylamine, pheniramine, phenyltoloxamine, promethazine, and triprolidine. Of the 338 accidents, 304 were general aviation accidents; 175 of the 338 pilots held private pilot airman certificates. Antihistamines were detected alone in 103 fatalities (1 antihistamine in 94 fatalities and 2 antihistamines in 9), while other drug(s) and/or ethanol were also present in an additional 235 fatalities. Thirty-five of the 338 fatalities had more than 1 antihistamine. The antihistamines were found in approximately 4 and 11% of the fatalities/accidents in 1990 and in 2004, respectively
Cataloging source
DTICE
http://library.link/vocab/creatorName
Sen, Ahmet
Government publication
federal national government publication
Index
no index present
Literary form
non fiction
Nature of contents
dictionaries
http://library.link/vocab/relatedWorkOrContributorName
  • United States
  • Gülhane Askeri Tıp Akademisi
http://library.link/vocab/subjectName
Aircraft accidents
Label
First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005, Ahmet Sen ... [and others]
Link
http://purl.access.gpo.gov/GPO/LPS116188
Instantiates
Publication
Note
  • Title from PDF title screen (viewed on Aug. 20, 2009)
  • "May 2007."
  • "DOT/FAA/AM-07/12."
  • This work was accomplished under the approved task AM-B-07-TOX-202
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
17616979
Extent
1 online resource (iii, 13 pages)
Form of item
electronic
Governing access note
APPROVED FOR PUBLIC RELEASE
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations
Label
First-generation H1 antihistamines found in pilot fatalities of civil aviation accidents, 1990-2005, Ahmet Sen ... [and others]
Link
http://purl.access.gpo.gov/GPO/LPS116188
Publication
Note
  • Title from PDF title screen (viewed on Aug. 20, 2009)
  • "May 2007."
  • "DOT/FAA/AM-07/12."
  • This work was accomplished under the approved task AM-B-07-TOX-202
Carrier category
online resource
Carrier category code
cr
Carrier MARC source
rdacarrier
Content category
text
Content type code
txt
Content type MARC source
rdacontent
Control code
17616979
Extent
1 online resource (iii, 13 pages)
Form of item
electronic
Governing access note
APPROVED FOR PUBLIC RELEASE
Media category
computer
Media MARC source
rdamedia
Media type code
c
Other physical details
illustrations

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